MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C9DD01.83FDE490" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold

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file:///C:/515CB117/zinc-colds-overview_files/master27.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii"
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------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/master27.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Zinc and the common cold:
aspects of solu= tion chemistry
and the
mouth-nose biologically closed electric circuit
=
George A. Eby
George Eby Research Institute
Austin, Texas =
Presented at the International Society for Trace Mineral Research, Crete, Greece in 2007
(updated April 23, 2009)
=
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This presentation is based upon:
nZinc Lozenges: Cold Cure or Candy?  Solution Chemistry Determinations, Geo= rge A. Eby, Bioscience Reports, Vol. 24, No. 1, February 2004.
n<= span style=3D'font-family:Garamond;mso-ascii-font-family:Garamond;font-size:75%; display:none'>
nSolution chemistry data supplied mainly by Guy Berthon, PhD, retired Directeur de Recherche CNRS Laboratoire de Chimie Bioinorganique Médicale, Université Paul Sabatier, Toulouse, France and editor of  Handbook = of Metal-ligand Interactions in Biologica= l Fluids: Bioinorganic Medicine .
n
nGeorge Eby Research Institute web site = http://george-eby-research.com
n<= span style=3D'font-family:Garamond;mso-ascii-font-family:Garamond;font-size:75%; display:none'>
nEby’s ColdCure web site = http://coldcure.com 
n<= span style=3D'font-family:Garamond;mso-ascii-font-family:Garamond;font-size:56%; mso-special-format:lastCR;display:none'>
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Some conflicting moments in the history of zinc and the common cold=
nMerck Index – 1901= , astringent zinc
sulphocarbolate nose drops as nasal decongestant – was not reported to shorten colds; neither was
eucalyptus oil and menthol.
nThe Practitioner  - 1936, Shields - astringent
zinc sulfate nasal packings with zinc ions driven
by electricity – prevented allergy & com= mon cold
symptoms for up to a year.
nAntimicrobial Agents and Chemotherapy  – 1984,
Eby, Davis and Halcomb – astringent zinc gluconate lozenges shortened colds by 7 days.
nAlternative Therapies in Health & Medicine  - 2006, Eby and Halcomb, - non-astringent zinc orotate lozenges & zinc <= span style=3D'position:absolute;top:78.75%;left:8.98%;width:84.45%;height:5.25%= '>gluconate nasal spray had no effect on common colds.
For over 100 years - much differenc= e in response – even by the same investigators (Eby and Halcomb)!=
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charset="us-ascii" Zinc and the common cold
Why the difference?
nDifferences in solution chemistry =
nTotal daily positively charged zinc species at pH 7.= 4 (iZn) (such as zinc gluconate and zinc acetate)  shortens c= olds in dose dependent manner – anti-rhinoviral (Korant and Butterworth, Journal o= f Virology, 1976).
nNeutral zinc species at pH 7.4 (such as zinc orotate) – no function .
nNegatively charged zinc species at pH 7.4 (such as zinc with multi ligands)– = worsens colds.
n
nFormulations and flavor issues
nZinc gluconate alone or in fructose-based lozenge – mild, chalky taste. &= #13;
nZinc gluconate mixed into dextrose or sucrose tablet bases over time – extremely bitter.
nRate of lozenge oral dissolution (Fick’s Laws of Membrane Permeability ap= ply)
nExistence of a mouth-nose biologically closed electric circuit
nInterior of nose is positively charged, while mouth is negatively charged.
nZinc ions from nasal application are repelled and may cause = anosmia.
------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0005.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
The mouth-nose Biologically Closed Electric Circuit
n “= Biologically Closed Electric Circuits” (BCEC)
were first described in 1993 by Björn E W
Nordenström, M.D., Professor Emeritus of
Diagnostic Radiology, Karolinska Institute and
Hospital of the Karolinska Institute in Stockholm
Sweden, written while he was chairman of the
n Nobel Prize Selection Committee for Physiology
and Medicine.
= n
= n 
nIn the = mouth-nose BCEC, electrons flow from
nose to mouth, and metallic ions flow from
mouth to nose.
nThe mouth-nose BCEC can be reversed using exogenous electricity.
nThe mouth-nose BCEC is the only BCEC observable externally in the human <= span style=3D'font-family:Garamond;mso-ascii-font-family:Garamond;font-size:63%= '>body.
nHad the mouth-nose BCEC not existed, the cure for the common cold (zinc = sulphocarbolate nose drops - Merck) would likely have been described in 1901.
n
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Mouth-nose BCEC details
nVoltages and resistances can be measured with
high quality digital volt-ohm meters. <= /span>
nIntra-subject voltages between interior of
mouth and interior of nose vary from 60 to 120 millivolts.
nIntra-subject resistances between interior of
mouth and interior of nose vary from 1,000 ohms to= 500,000 ohms.
nLow resistances (1,000 – 10,000 ohms) are found in people = that have very frequent colds and nasal allergies.
nMid range resistances (40,000 to 60,000 ohms) are found in most people.
nVery high resistances (100,000 to 500,000 ohms) are found in physicians and others that never have colds or allergies.
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cold
Lozenge formulation and flavor issues overview
n= SUCCESSFUL:
nAstringent and drying zinc gluconate lozenges were successful in both Eby et al., 1984 wild virus clinical trial and separately in the British MRC Common Cold Unit 1987 experimental rhinoviral infection clinical trial.
nAstringent and drying zinc gluconate with glycine (= ColdEeze™) lozenges were equivocally or modestly successful.
nAstringent and drying zinc acetate (without flavor masking agents) lozenges were successful in both Petrus et al. 1999 trial, the Prasad et al. 2000 trial and the Prasad et al. 2008 clinical trial.
n
nFAILED:
nNon-astringent and non-drying zinc gluconate (with citric acid flavor mask) = used in Bristol Myers trial failed.
Non-astringent and non-drying zinc orotate lozenges with zinc gluconate = nasal spray in the 2006 Eby and Halcomb report failed.
nNon-astringent and non drying zinc acetate lozenges by Faulding LTD flavor = masked with tartaric acid & sodium bicarbonate to produce effervescent = lozenges failed.
nNon-astringent and non drying zinc acetate lozenges by Warner Lambert, flavor masked by cooking zinc acetate with several fatty food acids failed.
------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0025.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Lozenge formulations are key
nEffective Re= altors say, “Location, location, location!” as being key to success.&= #13;= nGeorge Eby, inventor of cure for common cold using zinc lozenges, says about effective = zinc lozenges, “Formulation, formulation, formulation!” nLozenge formulations either make zinc lozenges work or make= them useless.
------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0024.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Astringent and drying means?
nPositively charged zinc species (ionic zinc, zinc ions, <= span style=3D'font-family:Garamond;mso-ascii-font-family:Garamond;font-size:88%= '>Zn2+, iZn) are astringent and drying in saliva of the mouth (at salivary pH – usually pH 5 to 5.5) (judged as = unpleasant mouth feel) nNon astringent or drying in saliva means either neutrally charged or negatively charged zinc species
------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0021.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Very brief overview of
solution chemistry
nWeak bonds between metal and ligand –&nb= sp; mainly ionic zinc (iZn) and neutral species (zinc gluconate, chloride & acetate)
nStrong bonds between metal and ligand – mainly neutral (zinc = orotate) and/or negative species (zinc citrate)
nNon soluble metal ligand compounds – non ionic (zinc oxide, zinc stearate and zinc oleate)
nAmounts of metal/ligand species are calculable – variables include metal and ligand stability constants, pH and pK values, concentrations and temperature
nLarge international solution chemistry databases
nOnly pH 7.4, physiologic pH is applicable for calculations of iZn=
------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0009.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Solution chemistry of zinc gluconate
= n
Green line =3D physiologi= c pH
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Solution chemistry of zinc gluconate
with glycine (1-2 and 1-10 = mol) as flavor mask (ColdEeze and related products)
<= span style=3D'font-size:25%;visibility:hidden'>n
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/Qmorj/En/IQi/64j/0JqKAP/9k= ------=_NextPart_01C9DD01.83FDE490 Content-Location: file:///C:/515CB117/zinc-colds-overview_files/slide0011.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Solution chemistry of zinc gluconate with
citric acid as flavor-mask
(used in many OTC zinc loze= nges in U.S.)
<= span style=3D'font-size:25%;visibility:hidden'>n
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file:///C:/515CB117/zinc-colds-overview_files/slide0010.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Solution chemistry of zinc acetate (used in Eby’s ColdCure)
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Sums of all positively charged zinc species
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file:///C:/515CB117/zinc-colds-overview_files/slide0014.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Zinc and the common cold
Reduction in common cold duration (days) in
clinical trials by daily iZn (mg/day)
(r > 0.727 and p < 0.02)
<= span style=3D'font-size:25%;visibility:hidden'>n
Legend: Green =3D single ligand.  Red =3D multiple ligands.
ZG =3D zinc gluconate, ZGG =3D zinc gluconate-glycinate, ZG-C= =3D zinc gluconate-citrate,
ZO =3D zinc orotate, ZA-SOP =3D zinc acetate-sterate-oleate-palmitate, ZA =3D zinc acetate,
ZA-TB =3D zinc acetate & tartaric acid / sodium bicarbona= te,
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