The following materials are provided for interested laymen and professionals wanting solid, factual information about the powerful, and beneficial effects of Zn²⁺ ions in treating common colds and other important illnesses. There are many internal and external links with links to movies of rhinoviruses from 3 different perspectives, and much more vital and accurate information than all but the most ardent professional can tolerate. But! The data are provided in easy to chew, byte size bits.

• NEW! "Zinc Lozenges: Cold Cure or Candy? Solution Chemistry Determinations" published in the February issue of Bioscience Reports. This is the latest peer reviewed article by George Eby.  It shows that the relationship of daily iZn [total daily positively charged zinc ions (in mg) at physiologic pH] from zinc lozenges in clinical trials is directly correlated with both median reduction in duration of common colds in days, and mean reduction of duration of common colds in days.

Legend: ZG = zinc gluconate, ZGG = zinc gluconate-glycinate, ZA = zinc acetate,
ZA-SOP = zinc acetate-sterate-oleate-palmitate, ZG-C = zinc gluconate-citrate.

• NEW! Zinc Lozenges: A Comparision of many different commercial zinc lozenges for efficacy.
  
  
• NEW! From the same report, as an extension: Solution chemistry determinations for: zinc acetate, zinc gluconate, zinc gluconate glycine and zinc citrate.
  
  
• "Does Zinc Really Cure the Common Cold? is quite brief, and is an excellent place to begin one's research in order to understand why only a very few zinc compounds out of many are effective against colds when incorporated into lozenges.
  
  
• Duration of Symptoms and Plasma Cytokine Levels in Patients with the Common Cold Treated with Zinc Acetate, Ananda S. Prasad, MD, PhD, et. al., Annals of Internal Medicine, August 15, 2000, Vol. 133, Pages 245-252. PDF Full Text Version This is a report of the efficacy of Eby's george-eby-research zinc acetate lozenge formula using 12.8 mg of zinc per lozenge.
  
  
• Petrus, Ed. "Randomized, Double-Matched, Placebo-Controlled, Clinical Study of the Effectiveness of Zinc Acetate Lozenges on Common Cold Symptoms in Allergy-Tested Subjects", Current Therapeutic Research, vol 59, no 9, pages 595-607, September 1998. This is a report of the efficacy of Eby's george-eby-research zinc acetate lozenge formula using 9.0 mg of zinc per lozenge.
  
  
• This 1988 article is the first to expose the enormous differences in chemistry between the lozenges used in the 1984 Eby et al. report and several other negative reports by authorities in the field: Eby, G. A., Stability Constants of Zinc Complexes Affect Common Cold Treatment Results, Antimicrobial Agents and Chemotherapy 1988;32:606-607.
  
  
• Why Zn²⁺ ions? In 1976 Korant and Butterworth found that Zn²⁺ ions from zinc chloride and zinc acetate complexes with rhinovirus coat proteins and alters them so that they cannot function as substrates for proteases or as reactants in the assembly of the virus particles.
• In 1991 evidence that zinc (Zn²⁺) ions are an effective inhibitor of protease C3, important due to its rate limiting effect on rhinovirus replication, can be inferred from its action on the poliovirus protease C3.
• Poliovirus and rhinovirus are members of the picornavirus RNA virus family.
• 2001 UPDATE of "Chapter 2: In Vitro Effects of Zn²⁺ ions" of my 1994 Handbook for Curing the Common Cold. Much broader in vitro information including the action of zinc in mediators of common cold symptoms is now available.
  
  
• The first peer reviewed report on the use of Zn²⁺ ions from throat lozenges to shorten the duration and severity of common colds: Eby, G. A., Davis D. R., Halcomb W. W., Reduction in Duration of Common Colds by Zinc Gluconate Lozenges in a Double Blind Study. Antimicrobial Agents and Chemotherapy 1984;25:20-24.
  
  
• The first and only study to replicate my original findings using live rhinovirus. The lozenges contained zinc gluconate, fructose and hydroxypropyl methylcellulose and were tested by the British Medical Council in 1987 and are reviewed in my handbook in Chapter 4.a.2.. The full article is presented here.
  
  
• Handbook for Curing the Common Cold -- the Zinc Lozenge Story Library of Congress Catalog Card Number: 93-090841, ISBN 0-9638967-0-9. This is a 100+ page book with 27 technical figures, 16 tables of data and complex mathematical expressions. The 1994 handbook is vital for the true common cold researcher. The price of the physical book is $299.95, as it has become a historical medical collector's item. But the virtual information is here -- free! Just for you! And, from the table of contents, list of figures, and list of tables, there are direct internal links to any topic you might desire.
  
  
• Taken from my 1994 handbook, my next peer reviewed article was published in the Journal of Pharmacy Technology in the May/June, 1995, issue. It is entitled Linearity in Dose-Response from Zinc Lozenges in Treatment of Common Colds. It is primarily for researchers wishing to quickly and conveniently: (a) obtain a strong scientific and technical understanding of the in vitro effects of Zn²⁺ ions, (b) understand the solution chemistry, biochemistry, and biophysics related to Zn²⁺ ions and common cold research, (c) review analyses of all pre-1996 published zinc lozenge for common cold reports, and (d) be introduced to the exciting technology behind zinc acetate lozenges. Unfortunately, this article was published in a journal that was not indexed by Index Medicus.
  
  
• "The Zinc Lozenge and Common Cold Story", in the internationally contributed, state-of-the-art, 4 volume set -- Metal-Ligand Interactions in Biological Fluids: Bioinorganic Medicine, Volume 2, pages 1182-1190, Marcel Dekker, Inc., New York, 1995. The editor (my mentor in solution chemistry), Guy Berthon, PhD, is Director of Research for Unit 305 (Equipe "Bioréaciifs : Spéciation et Biodisponibilité"), at the Institut National de la Santé et de la Recherché Médicale (INSERM), in Toulouse, France, a part of the Centre National de la Recherché Scientifque (CNRS), Paris, France. Dr. Berthon freely assisted in this article by computing zinc speciation by pH for several critical zinc compounds in solution.
  
  
• The most concise article on zinc lozenges and colds is the invited opinion Zinc lozenges as cure for common colds, Annals of Pharmacotherapy 1996:30;1336-1338. It is a 1770 word summary of the whole zinc lozenge for common colds enchilada -- and if you read the last three paragraphs carefully -- they will open a 21st century research gateway to cures for otherwise lethal viral infections, tissue necroses, anaphylactic shock, respiratory distress, and so forth. PubMed
  
  
• This peer reviewed article is indexed in Index Medicus Zinc Ion Availability: The Determinant of Efficacy in Zinc Lozenge Treatment of Common Colds, Journal of Antimicrobial Chemotherapy 1997:40;483-493. The full text of the article is presented here .
  
  
• Zinc ion availability and the common cold This is the published abstract of my oral presentation at the Vth Conference of The International Society for Trace Element Research in Humans (ISTERH) << New Aspects of Trace Element Research >> held in Lyon, France from 26th September to 1st October 1998.
  
  
• Cold-Eeze(r) Related Annals of Internal Medicine (AIM) articles The debate intensifies in the January 1, 1998 issue of AIM in the letters to the editor column. The public is first informed about the FDA's chief common cold consultant's vested financial interests in his own patented work.
  
  

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